Obesity Therapeutics
Inspired by Nature
Evolution has already run the experiment.
Animals have evolved extraordinary metabolic adaptations to survive conditions that would otherwise be incompatible with life. Periods of prolonged fasting. Extreme fluctuations in body weight. Massive shifts in energy expenditure. These biological solutions were refined over millions of years.
Arkana's platform begins with a simple idea: The answers to some of medicine's greatest challenges already exist in nature.
A massive market still waiting for better solutions.
GLP-1 medicines have reshaped obesity care, demonstrating that pharmacological treatment can produce meaningful weight loss and improve metabolic health. But tolerability challenges, cost, and high discontinuation rates leave many patients without a durable solution.
Obesity is a complex disease, and no single therapeutic approach works for everyone. Patients need a broader range of medicines that provide options for achieving and maintaining long-term weight loss. Our extreme biology platform enables us to discover this next generation of medicines.
1B+
$100B+
~50%
A Differentiated Pipeline
Two programs designed to address both sides of the energy-balance equation.
Both are oral, first-in-class small molecules. A deliberately differentiated profile in a market dominated by incretins.
ARK-100
An orally available small molecule that acts on the brain to reduce calorie intake. In proof-of-concept studies it cut food intake by half and drove meaningful weight loss, with better GI tolerability than incretin (GLP-1) therapies.
First-in-class appetite suppression biology
Differentiated on tolerability
Once-daily pill, not an injection
ARK-200
A mechanistically distinct program designed to increase energy expenditure — burning more calories at rest rather than suppressing appetite. Also conceived as a once-daily oral small molecule, ARK-200 is in early development.
Acts to raise basal calorie burn
Complementary to appetite-based approaches
Oral small molecule
Momentum
Nature Metabolism
Lead science peer-reviewed and published, 2026
$150,000
1st place, CU Boulder New Venture Challenge
$127,500
1st Place, CU Boulder Venture Partners Lab Venture Challenge
In the Media
Scientific innovation meets proven execution.
Arkana brings together experts in metabolism, drug discovery, and company building to translate nature's most remarkable biological adaptations into therapies for obesity and metabolic disease.
LEADERSHIP
Jack leads Arkana's strategy, operations, and fundraising. He completed his PhD studying the python feeding response and is a co-author of the company's foundational Nature Metabolism paper.
A repeat biotech founder and operator. Formerly CEO & co-founder of Mosaic Biosciences, CSO/COO of SomaLogic, and president & co-founder of both Dexela and Archemix.
A drug developer with 25+ years of R&D leadership across biotech and pharma, including VP of Preclinical Development at Regeneron, SVP of R&D at Adnexus (Bristol Myers Squibb), and CSO roles at Eleven Biotherapeutics and Mosaic Biosciences.
ADVISORS
Distinguished Professor at the University of Colorado and a pioneer of python physiology. Founder of three unicorn biotechs; MyoKardia, Myogen, and Kardigan.
Associate Professor at Stanford University, specializing in metabolomics and translating metabolite discoveries into therapeutics. Founder of Merrifield Therapeutics and Metabolize, and senior author of Arkana's Nature Metabolism study.
Assistant Professor at the University of Nebraska and a co-author of the company's Nature Metabolism paper, bringing deep expertise in muscle physiology and metabolism.
Help us turn extreme biology into medicine.
Arkana is an early-stage, Boulder-based company. We're looking for scientists who want real ownership of a program from its earliest days.
Discovery Program Lead
Lead the ARK-100 program from discovery toward the clinic. We're looking for a scientist with deep experience in metabolic disease and obesity, hands-on work with both in vitro and in vivo models, and a track record managing CROs. You'll own program execution and help build the team from the ground up.
don't see your role?
We are always looking for bright minds and enthusiastic people from diverse backgrounds, who want to be part of an outstanding team. Even if you don't find a suitable position below, please do not hesitate to drop us your resume.
